Positive and negative regulation of the Fcγ receptor–stimulating activity of RNA-containing immune complexes by RNase

Positive and negative regulation of the Fcγ receptor–stimulating activity of RNA-containing immune complexes by RNase

The U1RNP complex, Ro/SSA, and La/SSB are major RNA-containing autoantigens. Immune complexes (ICs) composed of RNA-containing autoantigens and autoantibodies are suspected to be involved in the pathogenesis of some systemic autoimmune diseases. Therefore, RNase treatment, which degrades RNA in ICs,...

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Bibliographic Details
Main Authors: Ryota Naito, Koichiro Ohmura, Shuhei Higuchi, Wataru Nakai, Masako Kohyama, Tsuneyo Mimori, Akio Morinobu, Hisashi Arase
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-08-01
Series:JCI Insight
Subjects:
Autoimmunity
Online Access:https://doi.org/10.1172/jci.insight.167799

Internet

https://doi.org/10.1172/jci.insight.167799

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