Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film

Diltiazem hydrochloride (HCl) is a category of calcium channel blocker used as an antihypertensive agent. Diltiazem HCl is a low bioavailable drug due to high first-pass metabolism and a short half-life (3-5 hours); hence mucoadhesive buccal film was made to overcome this weakness. Bioavailability o...

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Bibliographic Details
Main Authors: Lina Winarti, Bagus Tri Laksono, Lusia Oktora Ruma Kumala Sari
Format: Article
Language:English
Published: Universitas Gadjah Mada 2021-01-01
Series:Indonesian Journal of Pharmacy
Subjects:
Online Access:https://jurnal.ugm.ac.id/v3/IJP/article/view/995