GJA1/CX43 High Expression Levels in the Cervical Spinal Cord of ALS Patients Correlate to Microglia-Mediated Neuroinflammatory Profile

GJA1/CX43 High Expression Levels in the Cervical Spinal Cord of ALS Patients Correlate to Microglia-Mediated Neuroinflammatory Profile

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting motoneurons (MNs) with a fatal outcome. The typical degeneration of cortico-spinal, spinal, and bulbar MNs, observed in post-mortem biopsies, is associated with the activation of neuroimmune cells. GJA1, a memb...

Full description

Bibliographic Details
Main Authors: Nunzio Vicario, Paola Castrogiovanni, Rosa Imbesi, Sebastiano Giallongo, Giuliana Mannino, Debora Lo Furno, Rosario Giuffrida, Agata Zappalà, Giovanni Li Volti, Daniele Tibullo, Michelino Di Rosa, Rosalba Parenti
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biomedicines
Subjects:
GJA1
ALS
brain
bioinformatic
microglia
Online Access:https://www.mdpi.com/2227-9059/10/9/2246

Internet

https://www.mdpi.com/2227-9059/10/9/2246

Similar Items