In vitro culture expansion impairs chondrogenic differentiation and the therapeutic effect of mesenchymal stem cells by regulating the unfolded protein response

In vitro culture expansion impairs chondrogenic differentiation and the therapeutic effect of mesenchymal stem cells by regulating the unfolded protein response

Abstract In vitro expansion of mesenchymal stem cells (MSCs) has been implicated in loss of multipotency, leading to impaired chondrogenic potential and an eventual therapeutic effect, as reported in our previous study. However, the precise regulatory mechanism is still unclear. Here, we demonstrate...

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Bibliographic Details
Main Authors: Chong Shen, Tongmeng Jiang, Bo Zhu, Yiguan Le, Jianwei Liu, Zainen Qin, Haimin Chen, Gang Zhong, Li Zheng, Jinmin Zhao, Xingdong Zhang
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Biological Engineering
Subjects:
Endoplasmic reticulum stress
Unfolded protein response
Mesenchymal stem cells
Differentiation
Chondrogenesis
Online Access:http://link.springer.com/article/10.1186/s13036-018-0119-2

Internet

http://link.springer.com/article/10.1186/s13036-018-0119-2

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