Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11

Identification of novel targets of miR-622 in hepatocellular carcinoma reveals common regulation of cooperating genes and outlines the oncogenic role of zinc finger CCHC-type containing 11

The poor prognosis of advanced hepatocellular carcinoma (HCC) is driven by diverse features including dysregulated microRNAs inducing drug resistance and stemness. Lin-28 homolog A (LIN28A) and its partner zinc finger CCHC-type containing 11 (ZCCHC11) cooperate in binding, oligouridylation and subse...

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Bibliographic Details
Main Authors: Anne Gaza, Valerie Fritz, Lara Malek, Laura Wormser, Nora Treiber, Johannes Danner, Andreas E. Kremer, Wolfgang E. Thasler, Jürgen Siebler, Gunter Meister, Markus F. Neurath, Claus Hellerbrand, Anja K. Bosserhoff, Peter Dietrich
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Hepatocellular carcinoma
HCC
microRNA
drug resistance
ZCCHC11
Online Access:http://www.sciencedirect.com/science/article/pii/S147655862100021X

Internet

http://www.sciencedirect.com/science/article/pii/S147655862100021X

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