MD2 deficiency prevents high‐fat diet‐induced AMPK suppression and lipid accumulation through regulating TBK1 in non‐alcoholic fatty liver disease

MD2 deficiency prevents high‐fat diet‐induced AMPK suppression and lipid accumulation through regulating TBK1 in non‐alcoholic fatty liver disease

Abstract Background Non‐alcoholic fatty liver disease (NAFLD) is the most predominant form of liver diseases worldwide. Recent evidence shows that myeloid differentiation factor 2 (MD2), a protein in innate immunity and inflammation, regulates liver injury in models of NAFLD. Here, we investigated a...

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Bibliographic Details
Main Authors: Wu Luo, Lin Ye, Xue‐ting Hu, Mei‐hong Wang, Min‐xiu Wang, Lei‐ming Jin, Zhong‐xiang Xiao, Jian‐chang Qian, Yi Wang, Wei Zuo, Li‐jiang Huang, Guang Liang
Format: Article
Language:English
Published: Wiley 2022-03-01
Series:Clinical and Translational Medicine
Subjects:
AMPK/SREBP1
lipid accumulation
MD2
NAFLD
TBK1
Online Access:https://doi.org/10.1002/ctm2.777

Internet

https://doi.org/10.1002/ctm2.777

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