Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells

The pathogenesis of Huntington’s disease (HD), an inherited progressive neurodegenerative disease, is highly associated with the cytotoxicity-inducing mutant huntingtin (mHtt) protein. Emerging evidence indicates that autophagy plays a pivotal role in degrading aggregated proteins such as mHtt to en...

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Bibliographic Details
Main Authors: Yueshan Sun, Xueqin Jiang, Rong Pan, Xiaogang Zhou, Dalian Qin, Rui Xiong, Yiling Wang, Wenqiao Qiu, Anguo Wu, Jianming Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
Huntington’s disease
autophagy
mHtt
Aesculus chinensis Bge.
HT22 cells
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00116/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00116/full

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