Toll-like Receptor-9 (TLR-9) Signaling Is Crucial for Inducing Protective Immunity following Immunization with Genetically Modified Live Attenuated <i>Leishmania</i> Parasites

Toll-like Receptor-9 (TLR-9) Signaling Is Crucial for Inducing Protective Immunity following Immunization with Genetically Modified Live Attenuated <i>Leishmania</i> Parasites

No human vaccine is available for visceral leishmaniasis (VL). Live attenuated centrin gene-deleted <i>L. donovani</i> (<i>LdCen<sup>−/−</sup></i>) parasite vaccine has been shown to induce robust innate immunity and provide protection in animal models. Toll-like...

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Bibliographic Details
Main Authors: Parna Bhattacharya, Sreenivas Gannavaram, Nevien Ismail, Ankit Saxena, Pradeep K. Dagur, Adovi Akue, Mark KuKuruga, Hira L. Nakhasi
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pathogens
Subjects:
visceral leishmaniasis
dendritic cells
myeloid differentiation primary response 88
nuclear factor-kappa B
cytokines
costimulatory molecules
Online Access:https://www.mdpi.com/2076-0817/12/4/534

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https://www.mdpi.com/2076-0817/12/4/534

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