The SQSTM1/p62 UBA domain regulates Ajuba localisation, degradation and NF-κB signalling function

The SQSTM1/p62 UBA domain regulates Ajuba localisation, degradation and NF-κB signalling function

The LIM-domain containing protein Ajuba and the scaffold protein SQSTM1/p62 regulate signalling of NF-κB, a transcription factor involved in osteoclast differentiation and survival. The ubiquitin-associated domain of SQSTM1/p62 is frequently mutated in patients with Paget’s disease of bone. Here, we...

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Bibliographic Details
Main Authors: Melanie A. Sultana, Carmel Cluning, Wai-Sin Kwong, Nicole Polain, Nathan J. Pavlos, Thomas Ratajczak, John P. Walsh, Jiake Xu, Sarah L. Rea
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568271/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568271/?tool=EBI

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