Assessment of the impact of FcγRIIIA single-nucleotide polymorphisms on the efficacy of IgG1 monoclonal antibodies in patients with advanced gastroesophageal adenocarcinoma

Assessment of the impact of FcγRIIIA single-nucleotide polymorphisms on the efficacy of IgG1 monoclonal antibodies in patients with advanced gastroesophageal adenocarcinoma

Background: Immunoglobulin G1 (IgG1) monoclonal antibodies (mAbs), such as trastuzumab and ramucirumab, are utilized in advanced gastroesophageal adenocarcinoma (aGEA). The important mechanism of mAb therapeutic effect is engagement by natural killer (NK) cells via antibody-dependent cellular cytoto...

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Bibliographic Details
Main Authors: A.V. Serritella, N.K.S. Grewal, B. Peterson, K. Arndt, D.D. Gaudio, P. Liu, A. Shergill, B. Polite, H.L. Kindler, D.V.T. Catenacci, C.Y. Liao
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:ESMO Gastrointestinal Oncology
Subjects:
FcγRIIIA genotype
antibody-dependent cell-mediated cytotoxicity
IgG1 monoclonal antibodies
gastroesophageal adenocarcinoma
esophageal cancer
gastric cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2949819823000122

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http://www.sciencedirect.com/science/article/pii/S2949819823000122

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