Mineralocorticoid Receptor Antagonism Prevents Type 2 Familial Partial Lipodystrophy Brown Adipocyte Dysfunction

Mineralocorticoid Receptor Antagonism Prevents Type 2 Familial Partial Lipodystrophy Brown Adipocyte Dysfunction

Type-2 Familial Partial Lipodystrophy (FPLD2), a rare lipodystrophy caused by <i>LMNA</i> mutations, is characterized by a loss of subcutaneous fat from the trunk and limbs and excess accumulation of adipose tissue in the neck and face. Several studies have reported that the mineralocort...

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Bibliographic Details
Main Authors: Elisa Schena, Elisabetta Mattioli, Chiara Peres, Laura Zanotti, Paolo Morselli, Patricia Iozzo, Maria Angela Guzzardi, Chiara Bernardini, Monica Forni, Salvatore Nesci, Massimiliano Caprio, Carolina Cecchetti, Uberto Pagotto, Elena Gabusi, Luca Cattini, Gina Lisignoli, William Blalock, Alessandra Gambineri, Giovanna Lattanzi
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
type 2 familial partial lipodystrophy (FPLD2)
mineralocorticoid receptor (MR)
spironolactone
lamin A/C
prelamin A
adipose tissue
Online Access:https://www.mdpi.com/2073-4409/12/22/2586

Internet

https://www.mdpi.com/2073-4409/12/22/2586

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