MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis

MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis

In medulloblastomas, genetic alterations resulting in over-activation and/or deregulation of proteins involved in Hedgehog (HH) signaling lead to cellular transformation, which can be prevented by inhibition of primary ciliogenesis. Here, we investigated the role of MAPK15 in HH signaling and, in tu...

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Bibliographic Details
Main Authors: Silvia Pietrobono, Lorenzo Franci, Francesco Imperatore, Cristina Zanini, Barbara Stecca, Mario Chiariello
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
MAP Kinases
primary cilia
cancer stem cells
medullo-spheres
GLI1
Online Access:https://www.mdpi.com/2072-6694/13/19/4903

Internet

https://www.mdpi.com/2072-6694/13/19/4903

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