Transforming Growth Factor-β3/Recombinant Human-like Collagen/Chitosan Freeze-Dried Sponge Primed With Human Periodontal Ligament Stem Cells Promotes Bone Regeneration in Calvarial Defect Rats

Transforming Growth Factor-β3/Recombinant Human-like Collagen/Chitosan Freeze-Dried Sponge Primed With Human Periodontal Ligament Stem Cells Promotes Bone Regeneration in Calvarial Defect Rats

Patients with a skull defect are at risk of developing cerebrospinal fluid leakage and ascending bacterial meningitis at >10% per year. However, treatment with stem cells has brought great hope to large-area cranial defects. Having found that transforming growth factor (TGF)-β3 can promote th...

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Bibliographic Details
Main Authors: Shiyi Huang, Fenglin Yu, Yating Cheng, Yangfan Li, Yini Chen, Jianzhong Tang, Yu Bei, Qingxia Tang, Yueping Zhao, Yadong Huang, Qi Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
periodontal ligament stem cells
transforming growth factor 3
stem cell therapy
skull bone defect repair
freeze-dried sponge
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.678322/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.678322/full

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