Optimization and Biodistribution of [11C]-TKF, An Analog of Tau Protein Imaging Agent [18F]-THK523

Optimization and Biodistribution of [11C]-TKF, An Analog of Tau Protein Imaging Agent [18F]-THK523

The quantification of neurofibrillary tangles (NFTs) using specific PET tracers can facilitate the diagnosis of Alzheimer’s disease (AD) and allow monitoring of disease progression and treatment efficacy. [18F]-THK523 has shown high affinity and selectivity for tau pathology. However, its high reten...

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Bibliographic Details
Main Authors: Yanyan Kong, Yihui Guan, Fengchun Hua, Zhengwei Zhang, Xiuhong Lu, Tengfang Zhu, Bizeng Zhao, Jianhua Zhu, Cong Li, Jian Chen
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Molecules
Subjects:
Alzheimer’s disease
positron emission tomography (PET)
tau
neurofibrillary tangles (NFTs)
imaging
Online Access:http://www.mdpi.com/1420-3049/21/8/1019

Internet

http://www.mdpi.com/1420-3049/21/8/1019

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