Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area

Neighboring macrophage-induced alteration in the phenotype of colorectal cancer cells in the tumor budding area

Abstract Background A higher number of tumor buds in the invasive front of colorectal cancer (CRC) specimens has been shown to contribute to a poor prognosis in CRC patients. Because macrophages (Mφs) have been demonstrated to alter the phenotype of cancer cells, we hypothesized that the phenotype o...

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Bibliographic Details
Main Authors: Ichiro Kawamura, Rintaro Ohe, Kazushi Suzuki, Takanobu Kabasawa, Takumi Kitaoka, Daiichiro Takahara, Michihisa Kono, Naoya Uchiyama, Hiroaki Musha, Mitsuru Futakuchi, Fuyuhiko Motoi
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cancer Cell International
Subjects:
Colorectal cancer
Tumor budding
Topoisomerase 1
Tumor–stromal interaction
Macrophage
Histological spatial analysis
Online Access:https://doi.org/10.1186/s12935-024-03292-7

Internet

https://doi.org/10.1186/s12935-024-03292-7

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