MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer

MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer

Conventional transcriptome-wide association study (TWAS) approaches predict genetically regulated gene expression at the tissue level. Here, the authors develop a framework for cell-type-aware TWAS that predicts cell-type level expression from genotype data and identifies disease-associated genes wi...

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Bibliographic Details
Main Authors: Xiaoyu Song, Jiayi Ji, Joseph H. Rothstein, Stacey E. Alexeeff, Lori C. Sakoda, Adriana Sistig, Ninah Achacoso, Eric Jorgenson, Alice S. Whittemore, Robert J. Klein, Laurel A. Habel, Pei Wang, Weiva Sieh
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-35888-4

Internet

https://doi.org/10.1038/s41467-023-35888-4

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