A Straightforward Method for the Development of Positively Charged Gold Nanoparticle-Based Vectors for Effective siRNA Delivery

A Straightforward Method for the Development of Positively Charged Gold Nanoparticle-Based Vectors for Effective siRNA Delivery

The therapeutic potential of short interfering RNA (siRNA) to treat many diseases that are incurable with traditional preparations is limited by the extensive metabolism of serum nucleases, low permeability through biological membrane barriers because of a negative charge, and endosomal trapping. Ef...

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Bibliographic Details
Main Authors: Tatiana N. Elizarova, Maxim L. Antopolsky, Denis O. Novichikhin, Artemiy M. Skirda, Alexey V. Orlov, Vera A. Bragina, Petr I. Nikitin
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
siRNA delivery
cell-penetrating peptides
gold nanoparticles
secreted alkaline phosphatase
Online Access:https://www.mdpi.com/1420-3049/28/8/3318

Internet

https://www.mdpi.com/1420-3049/28/8/3318

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