Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics

Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics

We profile genome-wide histone 3 lysine 27 acetylation (H3K27ac) of 3 major brain cell types from hippocampus and dorsolateral prefrontal cortex (dlPFC) of subjects with and without Alzheimer’s Disease (AD). We confirm that single nucleotide polymorphisms (SNPs) associated with late onset AD (LOAD)...

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Bibliographic Details
Main Authors: Easwaran Ramamurthy, Gwyneth Welch, Jemmie Cheng, Yixin Yuan, Laura Gunsalus, David A. Bennett, Li-Huei Tsai, Andreas R. Pfenning
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Epigenomics
Alzheimer’s disease
brain cell types
genetics
genomics
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.948456/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.948456/full

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