Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose

Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose

The adenosine A2B receptor (A2BAR) is a member of a family of G-protein coupled receptors (GPCRs), which has a low affinity for adenosine and is now implicated in several pathophysiological conditions. We have demonstrated the beneficial effects of A2BAR activation in enhancing recovery after acute...

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Bibliographic Details
Main Authors: Giselle Sanchez-Guerrero, David S. Umbaugh, Abhay A. Ramachandran, Antonio Artigues, Hartmut Jaeschke, Anup Ramachandran
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Livers
Subjects:
acetaminophen
mitochondria
outer membrane
A2BAR
PGRMC1
Cyp2E1
Online Access:https://www.mdpi.com/2673-4389/4/1/2

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