pH-Dependent Compaction of the Intrinsically Disordered Poly-E Motif in Titin

The conformational sensitivity of intrinsically disordered proteins to shifts in pH due to their high degree of charged residues has been recognized for well over a decade. However, the role of the non-ionizable residues in this pH sensitivity remains poorly understood. Our lab has been investigatin...

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Bibliographic Details
Main Authors: Sophia Manukian, Gerrick E. Lindberg, Emily Punch, Sudarshi Premawardhana Dassanayake Mudiyanselage, Matthew J. Gage
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Biology
Subjects:
Online Access:https://www.mdpi.com/2079-7737/11/9/1302