Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status

Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status

<p>Abstract</p> <p>Background</p> <p>The detection of insulin autoantibodies (IAA) aids in the prediction of autoimmune diabetes development. However, the long-standing, gold standard <sup>125</sup>I-insulin radiobinding assay (RBA) has low reproducibility b...

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Bibliographic Details
Main Authors: Lo Bernice, Swafford Austin DE, Shafer-Weaver Kimberly A, Jerome Lawrence F, Rakhlin Luba, Mathern Douglas R, Callahan Conor A, Jiang Ping, Davison Lucy J, Stevens Helen E, Lucas Carrie L, White Jill, von Borstel Reid, Todd John A, Lenardo Michael J
Format: Article
Language:English
Published: BMC 2011-11-01
Series:Journal of Translational Medicine
Subjects:
NOD mice
diabetes
human autoantibodies
insulin
electrochemiluminescence
IAA
IA
ECL
Online Access:http://www.translational-medicine.com/content/9/1/203

Internet

http://www.translational-medicine.com/content/9/1/203

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