Differentiated Neurons Are More Vulnerable to Organophosphate and Carbamate Neurotoxicity than Undifferentiated Neurons Due to the Induction of Redox Stress and Accumulate Oxidatively-Damaged Proteins

Differentiated Neurons Are More Vulnerable to Organophosphate and Carbamate Neurotoxicity than Undifferentiated Neurons Due to the Induction of Redox Stress and Accumulate Oxidatively-Damaged Proteins

Organophosphate (OP) and carbamate pesticides are toxic to pests through targeted inhibition of acetylcholinesterase (AChE). However, OPs and carbamates may be harmful to non-target species including humans and could induce developmental neurotoxicity if differentiated or differentiating neurons are...

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Bibliographic Details
Main Authors: Anusha W. Mudyanselage, Buddhika C. Wijamunige, Artur Kocon, Wayne G. Carter
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Brain Sciences
Subjects:
aldicarb
azamethiphos
chlorpyrifos
cholinergic toxicity
developmental neurotoxicity
non-cholinergic mechanisms
Online Access:https://www.mdpi.com/2076-3425/13/5/728

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https://www.mdpi.com/2076-3425/13/5/728

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