Auxin-Inducible Degron System Reveals Temporal-Spatial Roles of HSF-1 and Its Transcriptional Program in Lifespan Assurance

Auxin-Inducible Degron System Reveals Temporal-Spatial Roles of HSF-1 and Its Transcriptional Program in Lifespan Assurance

HSF-1 is a key regulator of cellular proteotoxic stress response and is required for animal lifespan. In C. elegans, HSF-1 mediated heat shock response (HSR) declines sharply on the first day of adulthood, and HSF-1 was proposed to function primarily during larval stages for lifespan assurance based...

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Bibliographic Details
Main Authors: Allison C. Morphis, Stacey L. Edwards, Purevsuren Erdenebat, Lalit Kumar, Jian Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Aging
Subjects:
aging
proteostasis
heat shock factor
auxin-inducible degron
temporal-spatial function
core chaperome
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2022.899744/full

Internet

https://www.frontiersin.org/articles/10.3389/fragi.2022.899744/full

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