GABAA Receptor Subunit Composition Drives Its Sensitivity to the Insecticide Fipronil

GABAA Receptor Subunit Composition Drives Its Sensitivity to the Insecticide Fipronil

Fipronil (FPN) is a worldwide-used neurotoxic insecticide, targeting, and blocking GABAA receptors (GABAARs). Beyond its efficiency on insect GABAARs, FPN causes neurotoxic effects in humans and mammals. Here, we investigated the mode of action of FPN on mammalian α6-containing GABAARs to understand...

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Bibliographic Details
Main Authors: Zineb Soualah, Antoine Taly, Lucille Crespin, Ophélie Saulais, Daniel Henrion, Claire Legendre, Hélène Tricoire-Leignel, Christian Legros, César Mattei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Neuroscience
Subjects:
fipronil
GABAA receptor
synaptic/extrasynaptic receptor
voltage-clamp recording
cerebellum
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.768466/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.768466/full

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