Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression

Abstract Oxidative stress plays a pivotal role in the differentiation and proliferation of cells and programmed cell death. However, studies on the role of oxidative stress in differentiation have mainly employed the detection of reactive oxygen species (ROS) during differentiation or generated by R...

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Bibliographic Details
Main Authors: Sugako Oka, Teruhisa Tsuzuki, Masumi Hidaka, Mizuki Ohno, Yoshimichi Nakatsu, Mutsuo Sekiguchi
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00961-2