An Updated Review of Genetic Associations With Severe Adverse Drug Reactions: Translation and Implementation of Pharmacogenomic Testing in Clinical Practice

An Updated Review of Genetic Associations With Severe Adverse Drug Reactions: Translation and Implementation of Pharmacogenomic Testing in Clinical Practice

Adverse drug reactions (ADR) remain the major problems in healthcare. Most severe ADR are unpredictable, dose-independent and termed as type B idiosyncratic reactions. Recent pharmacogenomic studies have demonstrated the strong associations between severe ADR and genetic markers, including specific...

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Bibliographic Details
Main Authors: Chuang-Wei Wang, Ivan Arni C. Preclaro, Wei-Hsiang Lin, Wen-Hung Chung
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
adverse drug reactions
drug-induced liver injury
CYP
human leukocyte antigens
drug transporter
stevens-johnson syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.886377/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.886377/full

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