Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis

Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis

Abstract Drug resistance and poor treatment response are major obstacles to the effective treatment of acute myeloid leukemia (AML). A deeper understanding of the mechanisms regulating drug resistance and response genes in AML is therefore urgently needed. Our previous research has highlighted the i...

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Bibliographic Details
Main Authors: Xin Liu, Shuxin Zhong, Kangjie Qiu, Xi Chen, Weiyue Wu, Jiamian Zheng, Yanwen Liu, Haolong Wu, Shiyun Fan, Dingrui Nie, Xianfeng Wang, Zhi Yu, Ziwei Liao, Mengjun Zhong, Yangqiu Li, Chengwu Zeng
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Experimental Hematology & Oncology
Subjects:
NRF2
GPX4
Acute myeloid leukemia
Ferroptosis
Online Access:https://doi.org/10.1186/s40164-023-00411-4

Internet

https://doi.org/10.1186/s40164-023-00411-4

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