Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's Disease

The accumulation of beta amyloid (Aβ) can cause synaptic impairments, but the characteristics and mechanisms of the synaptic impairment induced by the accumulation of Aβ in Alzheimer's disease (AD) remain unclear. In identified single neurons in a newly developed Drosophila AD model, in which A...

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Bibliographic Details
Main Authors: Jian-Kang Huang, Ping-Li Ma, Su-Ying Ji, Xiao-Liang Zhao, Jiang-Xiu Tan, Xiao-Jiang Sun, Fu-De Huang
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003695