Ablation of GSDMD Attenuates Neurological Deficits and Neuropathological Alterations After Traumatic Brain Injury

Ablation of GSDMD Attenuates Neurological Deficits and Neuropathological Alterations After Traumatic Brain Injury

Pyroptosis plays a significant role in neuroinflammation after traumatic brain injury (TBI). However, the role of pyroptosis executor Gasdermin D (GSDMD) in neurological deficits and neuropathological alterations after TBI have not been elucidated. Our results demonstrated that GSDMD-KO exerted stri...

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Bibliographic Details
Main Authors: Hao Du, Chang-Hong Li, Ruo-Bing Gao, Xiao-Qing Cen, Ping Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular Neuroscience
Subjects:
GSDMD
NLRP3 inflammasome
traumatic brain injury
neuroinflammation
neuropathology
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.915969/full

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https://www.frontiersin.org/articles/10.3389/fncel.2022.915969/full

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