WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells

WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells

Abstract Background The Werner syndrome protein (WRN) belongs to the RecQ family of helicases and its loss of function results in the premature aging disease Werner syndrome (WS). We previously demonstrated that an early cellular change induced by WRN depletion is a posttranscriptional decrease in t...

Full description

Bibliographic Details
Main Authors: Juan Manuel Iglesias-Pedraz, Diego Matia Fossatti-Jara, Valeria Valle-Riestra-Felice, Sergio Rafael Cruz-Visalaya, Jose Antonio Ayala Felix, Lucio Comai
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Molecular and Cell Biology
Subjects:
Werner syndrome protein
mRNA export
NXF1 export receptor
Translation
Cancer
Senescence
Online Access:http://link.springer.com/article/10.1186/s12860-020-00315-9

Internet

http://link.springer.com/article/10.1186/s12860-020-00315-9

Similar Items