DAPTA, a C-C Chemokine Receptor 5 (CCR5), Leads to the Downregulation of Notch/NF-κB Signaling and Proinflammatory Mediators in CD40<sup>+</sup> Cells in Experimental Autoimmune Encephalomyelitis Model in SJL/J Mice

DAPTA, a C-C Chemokine Receptor 5 (CCR5), Leads to the Downregulation of Notch/NF-κB Signaling and Proinflammatory Mediators in CD40<sup>+</sup> Cells in Experimental Autoimmune Encephalomyelitis Model in SJL/J Mice

Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system characterized by motor deficits, cognitive impairment, fatigue, pain, and sensory and visual dysfunction. CD40, highly expressed in B cells, plays a significant role in MS pathogenesis. The experimental autoi...

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Bibliographic Details
Main Authors: Hanan Alghibiwi, Mushtaq A. Ansari, Ahmed Nadeem, Majed Ali Algonaiah, Sabry M. Attia, Saleh A. Bakheet, Thamer H. Albekairi, Sultan Almudimeegh, Abdullah S. Alhamed, Mudassar Shahid, Mohammad Y. Alwetaid, Yasseen A. Alassmrry, Sheikh F. Ahmad
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biomedicines
Subjects:
CCR5 antagonist
Notch signaling
NF-κB/IκB-α
B lymphocytes
EAE
multiple sclerosis
Online Access:https://www.mdpi.com/2227-9059/11/6/1511

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https://www.mdpi.com/2227-9059/11/6/1511

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