REGA-SIGN: Development of a Novel Set of NanoBRET-Based G Protein Biosensors

Despite G protein-coupled receptors (GPCRs) being important theapeutic targets, the signaling properties of many GPCRs remain poorly characterized. GPCR activation primarily initiates heterotrimeric G protein signaling. To detect ligand-induced G protein activation, Bioluminescence Resonance Energy...

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Bibliographic Details
Main Authors: Katrijn Boon, Nathan Vanalken, Eef Meyen, Dominique Schols, Tom Van Loy
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biosensors
Subjects:
Online Access:https://www.mdpi.com/2079-6374/13/8/767