Unmasking Heavily O-Glycosylated Serum Proteins Using Perchloric Acid: Identification of Serum Proteoglycan 4 and Protease C1 Inhibitor as Molecular Indicators for Screening of Breast Cancer.

Unmasking Heavily O-Glycosylated Serum Proteins Using Perchloric Acid: Identification of Serum Proteoglycan 4 and Protease C1 Inhibitor as Molecular Indicators for Screening of Breast Cancer.

Heavily glycosylated mucin glycopeptides such as CA 27.29 and CA 15-3 are currently being used as biomarkers for detection and monitoring of breast cancer. However, they are not well detected at the early stages of the cancer. In the present study, perchloric acid (PCA) was used to enhance detection...

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Bibliographic Details
Main Authors: Cheng-Siang Lee, Nur Aishah Mohd Taib, Ali Ashrafzadeh, Farhana Fadzli, Faizah Harun, Kartini Rahmat, See Mee Hoong, Puteri Shafinaz Abdul-Rahman, Onn Haji Hashim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4758733?pdf=render

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http://europepmc.org/articles/PMC4758733?pdf=render

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