Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet.

Hepatocyte-Specific Depletion of UBXD8 Induces Periportal Steatosis in Mice Fed a High-Fat Diet.

We showed previously that UBXD8 plays a key role in proteasomal degradation of lipidated ApoB in hepatocarcinoma cell lines. In the present study, we aimed to investigate the functions of UBXD8 in liver in vivo. For this purpose, hepatocyte-specific UBXD8 knockout (UBXD8-LKO) mice were generated. Th...

Full description

Bibliographic Details
Main Authors: Norihiro Imai, Michitaka Suzuki, Kazuhiko Hayashi, Masatoshi Ishigami, Yoshiki Hirooka, Takaya Abe, Go Shioi, Hidemi Goto, Toyoshi Fujimoto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4430229?pdf=render

Internet

http://europepmc.org/articles/PMC4430229?pdf=render

Similar Items