Nanobody engineering for SARS-CoV-2 neutralization and detection

Nanobody engineering for SARS-CoV-2 neutralization and detection

ABSTRACTIn response to the ongoing COVID-19 pandemic, the quest for coronavirus inhibitors has inspired research on a variety of small proteins beyond conventional antibodies, including robust single-domain antibody fragments, i.e., “nanobodies.” Here, we explore the potential of nanobody engineerin...

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Bibliographic Details
Main Authors: Liina Hannula, Suvi Kuivanen, Jonathan Lasham, Ravi Kant, Lauri Kareinen, Mariia Bogacheva, Tomas Strandin, Tarja Sironen, Jussi Hepojoki, Vivek Sharma, Petri Saviranta, Anja Kipar, Olli Vapalahti, Juha T. Huiskonen, Ilona Rissanen
Format: Article
Language:English
Published: American Society for Microbiology 2024-04-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
nanobody
virus neutralization
protein engineering
diagnostics
Online Access:https://journals.asm.org/doi/10.1128/spectrum.04199-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.04199-22

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