Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression

Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression

Abstract Background Spreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neurons and glial cells. This phenomenon is repetitive and produces a metabolic overload that increases secondary damage. However, the mechanisms associated with...

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Bibliographic Details
Main Authors: Juan E. Tichauer, Matías Lira, Waldo Cerpa, Juan A. Orellana, Juan C. Sáez, Maximiliano Rovegno
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Biological Research
Subjects:
Spreading depression
Connexin-43
Pannexin-1
Astrocyte
Neurons
Synaptic transmission
Online Access:https://doi.org/10.1186/s40659-024-00519-9

Internet

https://doi.org/10.1186/s40659-024-00519-9

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