Activation of natural killer cells by rituximab in granulomatosis with polyangiitis

Activation of natural killer cells by rituximab in granulomatosis with polyangiitis

Abstract Objective In the last few years, anti-CD20 antibody rituximab profoundly changed the therapeutic landscape of granulomatosis with polyangiitis (GPA). Here, we investigated whether natural killer (NK) cells may play a role in rituximab’s mechanism of action in GPA. Methods B cell depletion,...

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Bibliographic Details
Main Authors: Doris Urlaub, Shuyang Zhao, Norbert Blank, Raoul Bergner, Maren Claus, Theresa Tretter, Hanns-Martin Lorenz, Carsten Watzl, Wolfgang Merkt
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Arthritis Research & Therapy
Subjects:
Natural killer cells
Rituximab
B cell depletion
Rheumatic diseases
ANCA-associated vasculitis
Granulomatosis with polyangiitis
Online Access:https://doi.org/10.1186/s13075-019-2054-0

Internet

https://doi.org/10.1186/s13075-019-2054-0

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