B-cell gene therapy for tolerance induction: host but not donor B cell derived IL-10 is necessary for tolerance

B-cell gene therapy for tolerance induction: host but not donor B cell derived IL-10 is necessary for tolerance

Genetically modified B cells are excellent tolerogenic APCs in multiple models of autoimmunity. However, the mechanisms of action are still not completely understood. In our models, we generate antigen-specific tolerogenic B cells by transducing naïve or primed B cells with an antigen-immun...

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Bibliographic Details
Main Authors: Yan eSu, Ai-Hong eZhang, Nancy eNoben-Trauth, David William Scott
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-07-01
Series:Frontiers in Microbiology
Subjects:
Gene Therapy
tolerance
IL-10
B cells
IL-10 receptor
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00154/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2011.00154/full

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