Mutated KIT Tyrosine Kinase as a Novel Molecular Target in Acute Myeloid Leukemia

Mutated KIT Tyrosine Kinase as a Novel Molecular Target in Acute Myeloid Leukemia

KIT is a type-III receptor tyrosine kinase that contributes to cell signaling in various cells. Since KIT is activated by overexpression or mutation and plays an important role in the development of some cancers, such as gastrointestinal stromal tumors and mast cell disease, molecular therapies targ...

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Bibliographic Details
Main Authors: Seiichiro Katagiri, SungGi Chi, Yosuke Minami, Kentaro Fukushima, Hirohiko Shibayama, Naoko Hosono, Takahiro Yamauchi, Takanobu Morishita, Takeshi Kondo, Masamitsu Yanada, Kazuhito Yamamoto, Junya Kuroda, Kensuke Usuki, Daigo Akahane, Akihiko Gotoh
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
acute myeloid leukemia
genome profiling
<i>KIT</i> mutation
<i>RUNX1</i>-<i>RUNX1T1</i>
HSP90 inhibitor
Online Access:https://www.mdpi.com/1422-0067/23/9/4694

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https://www.mdpi.com/1422-0067/23/9/4694

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