Antiepileptic Effect and Safety Profile of Rapamycin in Pediatric Patients With Tuberous Sclerosis Complex

Antiepileptic Effect and Safety Profile of Rapamycin in Pediatric Patients With Tuberous Sclerosis Complex

BackgroundEpilepsy develops in 70–90% of children with Tuberous Sclerosis Complex (TSC) and is often resistant to medication. Treatment with mTOR pathway inhibitors is an important therapeutic option in drug-resistant epilepsy associated with TSC. Our study evaluated the antiepileptic effect of rapa...

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Bibliographic Details
Main Authors: Krzysztof Sadowski, Kamil Sijko, Dorota Domańska-Pakieła, Julita Borkowska, Dariusz Chmielewski, Agata Ulatowska, Sergiusz Józwiak, Katarzyna Kotulska
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Neurology
Subjects:
tuberous sclerosis
epilepsy
rapamycin
sirolimus
mTOR inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.704978/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2022.704978/full

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