Aerobic Exercise Restores Aging‐Associated Reductions in Arterial Adropin Levels and Improves Adropin‐Induced Nitric Oxide‐Dependent Vasorelaxation

Aerobic Exercise Restores Aging‐Associated Reductions in Arterial Adropin Levels and Improves Adropin‐Induced Nitric Oxide‐Dependent Vasorelaxation

Background Adropin is a peptide hormone that promotes nitric oxide (NO) production via activation of endothelial NO synthase (eNOS) in endothelial cells. Its circulating levels are reduced with aging and increased with aerobic exercise training (AT). Using a mouse model, we hypothesized that AT rest...

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Bibliographic Details
Main Authors: Shumpei Fujie, Natsuki Hasegawa, Naoki Horii, Masataka Uchida, Kiyoshi Sanada, Takafumi Hamaoka, Jaume Padilla, Luis A. Martinez‐Lemus, Seiji Maeda, Motoyuki Iemitsu
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
adropin
aging
exercise training
nitric oxide
vasodilation
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.020641

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.020641

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