CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects

CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects

Post-mortem studies consistently show evidence of reduced synaptic protein levels in patients with schizophrenia. Clinically high-risk subjects show a steeper decrease in grey matter thickness and in vitro modeling using patient-derived cells implicate excessive synaptic pruning during neurodevelopm...

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Bibliographic Details
Main Authors: Chengai Xu, Carl M. Sellgren, Helena Fatouros-Bergman, Fredrik Piehl, Kaj Blennow, Henrik Zetterberg, Ann Brinkmalm, Alexander Frizell Santillo, Sofia Lundgren, Simon Cervenka, Göran Engberg, Sophie Erhardt
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:IBRO Reports
Subjects:
Schizophrenia
Synapse pruning
SNAP-25
SYT-1
Online Access:http://www.sciencedirect.com/science/article/pii/S245183012030011X

Internet

http://www.sciencedirect.com/science/article/pii/S245183012030011X

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