Wiggle and Shake: Managing and Exploiting Conformational Dynamics during Proteasome Biogenesis

Wiggle and Shake: Managing and Exploiting Conformational Dynamics during Proteasome Biogenesis

The 26S proteasome is the largest and most complicated protease known, and changes to proteasome assembly or function contribute to numerous human diseases. Assembly of the 26S proteasome from its ~66 individual polypeptide subunits is a highly orchestrated process requiring the concerted actions of...

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Bibliographic Details
Main Authors: Daniel Betancourt, Tomiwa Lawal, Robert J. Tomko
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biomolecules
Subjects:
26S proteasome
ubiquitin
proteolysis
ATPase
macromolecular assembly
chaperone
Online Access:https://www.mdpi.com/2218-273X/13/8/1223

Internet

https://www.mdpi.com/2218-273X/13/8/1223

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