The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase
Abstract Hypophosphatasia (HPP) is a metabolic bone disease that manifests as developmental abnormalities in bone and dental tissues. HPP patients exhibit hypo-mineralization and osteopenia due to the deficiency or malfunction of tissue non-specific alkaline phosphatase (TNAP), which catalyzes the h...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-07-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-39833-3 |