The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase

The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase

Abstract Hypophosphatasia (HPP) is a metabolic bone disease that manifests as developmental abnormalities in bone and dental tissues. HPP patients exhibit hypo-mineralization and osteopenia due to the deficiency or malfunction of tissue non-specific alkaline phosphatase (TNAP), which catalyzes the h...

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Bibliographic Details
Main Authors: Yating Yu, Kewei Rong, Deqiang Yao, Qing Zhang, Xiankun Cao, Bing Rao, Ying Xia, Yi Lu, Yafeng Shen, Ying Yao, Hongtao Xu, Peixiang Ma, Yu Cao, An Qin
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39833-3

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