Drug-target binding quantitatively predicts optimal antibiotic dose levels in quinolones.

Drug-target binding quantitatively predicts optimal antibiotic dose levels in quinolones.

Antibiotic resistance is rising and we urgently need to gain a better quantitative understanding of how antibiotics act, which in turn would also speed up the development of new antibiotics. Here, we describe a computational model (COMBAT-COmputational Model of Bacterial Antibiotic Target-binding) t...

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Bibliographic Details
Main Authors: Fabrizio Clarelli, Adam Palmer, Bhupender Singh, Merete Storflor, Silje Lauksund, Ted Cohen, Sören Abel, Pia Abel Zur Wiesch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-08-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1008106

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https://doi.org/10.1371/journal.pcbi.1008106

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