Epigenetic Alterations in Prenatal Stress Mice as an Endophenotype Model for Schizophrenia: Role of Metabotropic Glutamate 2/3 Receptors

Epigenetic Alterations in Prenatal Stress Mice as an Endophenotype Model for Schizophrenia: Role of Metabotropic Glutamate 2/3 Receptors

Mice subjected to prenatal restraint stress (PRS mice) showed biochemical and behavioral abnormalities consistent with a schizophrenia-like phenotype (Matrisciano et al., 2016). PRS mice are characterized by increased DNA-methyltransferase 1 (DNMT1) and ten-eleven methylcytosine dioxygenase 1 (TET1)...

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Bibliographic Details
Main Authors: Francesco Matrisciano, Erbo Dong, Ferdinando Nicoletti, Alessandro Guidotti
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mGlu2/3 receptors
schizophrenia
clozapine
epigenetics
prenatal stress
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00423/full

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https://www.frontiersin.org/article/10.3389/fnmol.2018.00423/full

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