The Subtype Selectivity in Search of Potent Hypotensive Agents among 5,5-Dimethylhydantoin Derived α<sub>1</sub>-Adrenoceptors Antagonists

The Subtype Selectivity in Search of Potent Hypotensive Agents among 5,5-Dimethylhydantoin Derived α<sub>1</sub>-Adrenoceptors Antagonists

In order to find new hypotensive drugs possessing higher activity and better selectivity, a new series of fifteen 5,5-dimethylhydantoin derivatives (<b>1</b>–<b>15</b>) was designed. Three-step syntheses, consisting of N-alkylations using standard procedures as well as microw...

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Bibliographic Details
Main Authors: Aneta Kaczor, Joanna Knutelska, Katarzyna Kucwaj-Brysz, Małgorzata Zygmunt, Ewa Żesławska, Agata Siwek, Marek Bednarski, Sabina Podlewska, Magdalena Jastrzębska-Więsek, Wojciech Nitek, Jacek Sapa, Jadwiga Handzlik
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
α<sub>1</sub>-adrenoceptor
5,5-dimethylhydantoin
crystallography
molecular modelling
α<sub>1A</sub>
α<sub>1B</sub>
Online Access:https://www.mdpi.com/1422-0067/24/23/16609

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https://www.mdpi.com/1422-0067/24/23/16609

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