Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents

Variability of murine bacterial pneumonia models used to evaluate antimicrobial agents

Antimicrobial resistance has become one of the greatest threats to human health, and new antibacterial treatments are urgently needed. As a tool to develop novel therapies, animal models are essential to bridge the gap between preclinical and clinical research. However, despite common usage of in vi...

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Bibliographic Details
Main Authors: Rakel Arrazuria, Bernhard Kerscher, Karen E. Huber, Jennifer L. Hoover, Carina Vingsbo Lundberg, Jon Ulf Hansen, Sylvie Sordello, Stephane Renard, Vincent Aranzana-Climent, Diarmaid Hughes, Philip Gribbon, Lena E. Friberg, Isabelle Bekeredjian-Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Microbiology
Subjects:
murine pneumonia model
antimicrobial
lung infection
Gram-negative
PK/PD
antimicrobial efficacy studies
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.988728/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.988728/full

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