Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction.

Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction.

Reversal reactions (RRs) in leprosy are characterized by a reduction in the number of bacilli in lesions associated with an increase in cell-mediated immunity against the intracellular bacterium Mycobacterium leprae, the causative pathogen of leprosy. To identify the mechanisms that contribute to ce...

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Bibliographic Details
Main Authors: Rosane M B Teles, Jing Lu, Maria Tió-Coma, Isabela M B Goulart, Sayera Banu, Deanna Hagge, Kidist Bobosha, Tom H M Ottenhoff, Matteo Pellegrini, Annemieke Geluk, Robert L Modlin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-10-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0007764

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https://doi.org/10.1371/journal.pntd.0007764

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